Synthesis, structural characterization and antiproliferative activity on MCF-7 and A549 tumor cell lines of [Cu(N-N)(beta(3)-aminoacidate)] NO3 complexes (Casiopeinas (R)

Abstract

The synthesis of three new mixed chelate copper (II) nitrate coordination compounds of the general formula {[Cu(phen)(L)(solv)NO3 center dot 0-0.5(solv)} is reported, where phen is 1,10-phenanthroline and L is a beta(3)-aminoacidate (beta-alaninate for 1, 3-aminobutanoate for 2 and 3-amino-3-cyclohexylpropanoate for 3), and the solvent (solv) is H2O and/or MeOH. The complexes were characterized by elemental analysis, IR and UV-Vis spectrophotometry, EPR spectroscopy, effective magnetic moment, conductometric and cyclovoltammetric measurements as well as single-crystal X-ray diffraction (SCXRD) analysis. All complexes are mononuclear Cu(II) complexes with d(9) configuration. In solution, the compounds are 1:1 electrolytes and exhibit square-based pyramidal coordination polyhedra. Meanwhile, in the solid state the coordination geometries are square-based pyramidal for compounds 1 and 2, but distorted octahedral for compound 3 due to coordination of the nitrate counterion. In vitro studies revealed that compounds 1, 2 and 3 have growth inhibition activity against MCF-7 and A549 tumor cell lines. The clustering of the experimental half-wave potential values among the three complexes could be explained by the fact of that the substitution pattern was changed on the secondary ligand, while the primary ligand remains without any structural modification.